Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide

Ben Yao; Zhining Xu; Jianan Liu; Liang Yang; Jianping Shang; Jingyuan Fan; Lizhi Ouyang; Hua-Jun Shawn Fan

doi:doi:10.11648/j.ajset.20230801.14

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Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide

Ben Yao, Zhining Xu, Jianan Liu, Liang Yang, Jianping Shang, Jingyuan Fan, Lizhi Ouyang, Hua-Jun Shawn Fan

Published in American Journal of Science, Engineering and Technology (Volume 8, Issue 1)

Received: 14 November 2022 Accepted: 12 December 2022 Published: 16 February 2023

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Abstract

Various factors such as solubility, volatility, spray drift, runoff, and photolysis prevent the pesticides to reach their desired location and realize their full potential. In this study, additive manufacturing is used to create a drug-loaded filament that can be used in Fused deposition modeling printing. The optimal printing parameters are printing temperature (170°C), hotbed temperature (25°C), printing speed 15 mm/s, filament diameter 1.55 mm, layer height 0.3 mm, nozzle diameter 0.4 mm and zero retraction speed and retraction distance. The PCL-based framework provides a scaffold for drug encapsulation and low melting temperature. The latter is the key to maintaining the integrity and chemical properties of the loaded drug. FTIR confirms the physical-mix nature of composite. XRD suggests that PCL and model drug became amorphous after printing. The PCL controlled-release can be realized through in vitro dissolution tests. Among the four kinetic models: the zero-order, first-order, Higuchi model, and Korsmeyer–Peppas model, the kinetic model for dissolution and drug release conforms to the Korsmeyer–Peppas model. This study provides a viable design of controlled-release pesticides by adjusting the release regulator content and type to meet the precision pest-control needs. This 3DP tablet has higher drug loading, controllable drug loading, stable drug release ability, UV shielding performance, and an easy manufacturing process. There is no need for expensive and special equipment to produce the desired functionality, which greatly reduces production costs and simplifies the production process.

Published in	American Journal of Science, Engineering and Technology (Volume 8, Issue 1)
DOI	10.11648/j.ajset.20230801.14
Page(s)	33-41
Creative Commons	This is an Open Access article, distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium or format, provided the original work is properly cited.
Copyright	Copyright © The Author(s), 2024. Published by Science Publishing Group

Keywords

3D Printing Pesticide, Controlled-Release, Fused Deposition Modeling, Poly ε-caprolactone, Hydroxypropyl Methylcellulose

References

[1]	Raileanu, M., et al., Sol-gel materials with pesticide delivery properties. Journal of Environmental Protection, 2010. 1 (03): p. 302.
[2]	Hao, L., et al., Composite pesticide nanocarriers involving functionalized boron nitride nanoplatelets for pH-responsive release and enhanced UV stability. Chemical Engineering Journal, 2020. 396: p. 125233.
[3]	Knowles, A., Recent developments of safer formulations of agrochemicals. The Environmentalist, 2008. 28 (1): p. 35-44.
[4]	Pan, B., et al., Comparative efficacy of oil solution and wettable powder of lambda-cyhalothrin to naturally occurring Ornithonyssus sylviarum infestation of chickens. Veterinary parasitology, 2009. 164 (2-4): p. 353-356.
[5]	Massinon, M., et al., Spray droplet impaction outcomes for different plant species and spray formulations. Crop Protection, 2017. 99: p. 65-75.
[6]	Nuruzzaman, M., et al., Nanoencapsulation, nano-guard for pesticides: a new window for safe application. Journal of agricultural and food chemistry, 2016. 64 (7): p. 1447-1483.
[7]	Cui, B., et al., Emamectin benzoate-loaded zein nanoparticles produced by antisolvent precipitation method. Polymer Testing, 2021. 94.
[8]	He, F., et al., Fabrication of a sustained release delivery system for pesticides using interpenetrating polyacrylamide/alginate/montmorillonite nanocomposite hydrogels. Applied Clay Science, 2019. 183.
[9]	Septiyanti, M., Evaluation of Nanoemulsion Concentrate Botanical Fungicide from Neem, Citronella and Eugenol Oil Using Palm Oil Based Surfactant. American Journal of Physics and Applications, 2019. 7 (1).
[10]	Wang, Y., et al., A new temperature-responsive controlled-release pesticide formulation – poly (N-isopropylacrylamide) modified graphene oxide as the nanocarrier for lambda-cyhalothrin delivery and their application in pesticide transportation. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 2021. 612.
[11]	Vega-Vasquez, P., N. S. Mosier, and J. Irudayaraj, Nanoscale Drug Delivery Systems: From Medicine to Agriculture. Frontiers in Bioengineering and Biotechnology, 2020. 8.
[12]	Oztemel, E. and S. Gursev, Literature review of Industry 4.0 and related technologies. Journal of Intelligent Manufacturing, 2018. 31 (1): p. 127-182.
[13]	Mohammed, A., et al., Additive Manufacturing Technologies for Drug Delivery Applications. Int J Pharm, 2020. 580: p. 119245.
[14]	Ligon, S. C., et al., Polymers for 3D Printing and Customized Additive Manufacturing. Chem Rev, 2017. 117 (15): p. 10212-10290.
[15]	Chen, Z., et al., 3D printing of ceramics: A review. Journal of the European Ceramic Society, 2019. 39 (4): p. 661-687.
[16]	Araujo, M. R. P., et al., The Digital Pharmacies Era: How 3D Printing Technology Using Fused Deposition Modeling Can Become a Reality. Pharmaceutics, 2019. 11 (3).
[17]	Mazzanti, V., L. Malagutti, and F. Mollica, FDM 3D Printing of Polymers Containing Natural Fillers: A Review of their Mechanical Properties. Polymers (Basel), 2019. 11 (7).
[18]	Bandari, S., et al., Coupling hot melt extrusion and fused deposition modeling: Critical properties for successful performance. Adv Drug Deliv Rev, 2021. 172: p. 52-63.
[19]	Pereira, G. G., et al., Polymer Selection for Hot-Melt Extrusion Coupled to Fused Deposition Modelling in Pharmaceutics. Pharmaceutics, 2020. 12 (9).
[20]	Peres, M. C., et al., In natura and nanoencapsulated essential oils from Xylopia aromatica reduce oviposition of Bemisia tabaci in Phaseolus vulgaris. Journal of Pest Science, 2020. 93 (2): p. 807-821.
[21]	Moore, A. J. S., et al., Bioreactivity of a novel poly (epsilon-caprolactone) nanocapsule containing atrazine with human lung alveolar epithelial cells. Environmental Science: Nano, 2022. 9 (6): p. 2134-2148.
[22]	Mun, A., et al., Alginate hydrogel beads embedded with drug-bearing polycaprolactone microspheres for sustained release of paclobutrazol. Sci Rep, 2021. 11 (1): p. 10877.
[23]	Dai, Y., et al., Determination of starch gelatinization temperatures by an automated headspace gas chromatography. Journal of Chromatography A, 2019. 1602: p. 419-424.
[24]	Elbl, J., J. Gajdziok, and J. Kolarczyk, 3D printing of multilayered orodispersible films with in-process drying. International Journal of Pharmaceutics, 2020. 575.
[25]	Rodriguez-Pombo, L., et al., Volumetric 3D printing for rapid production of medicines. Additive Manufacturing, 2022. 52.
[26]	Yang, Y., et al., 3D-printed polycaprolactone-chitosan based drug delivery implants for personalized administration. Materials & Design, 2022. 214.
[27]	Sethi, S., et al., Cross-linked xanthan gum-starch hydrogels as promising materials for controlled drug delivery. Cellulose, 2020. 27 (8): p. 4565-4589.
[28]	Tedesco, M. P., et al., Production of oral films based on pre-gelatinized starch, CMC and HPMC for delivery of bioactive compounds extract from acerola industrial waste. Industrial Crops and Products, 2021. 170.
[29]	Fina, F., et al., 3D Printing of Tunable Zero-Order Release Printlets. Polymers (Basel), 2020. 12 (8).
[30]	Costa, P. and J. M. Sousa Lobo, Modeling and comparison of dissolution profiles. European Journal of Pharmaceutical Sciences, 2001. 13 (2): p. 123-133.

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APA Style

Ben Yao, Zhining Xu, Jianan Liu, Liang Yang, Jianping Shang, et al. (2023). Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide. American Journal of Science, Engineering and Technology, 8(1), 33-41. https://doi.org/10.11648/j.ajset.20230801.14

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ACS Style

Ben Yao; Zhining Xu; Jianan Liu; Liang Yang; Jianping Shang, et al. Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide. Am. J. Sci. Eng. Technol. 2023, 8(1), 33-41. doi: 10.11648/j.ajset.20230801.14

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AMA Style

Ben Yao, Zhining Xu, Jianan Liu, Liang Yang, Jianping Shang, et al. Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide. Am J Sci Eng Technol. 2023;8(1):33-41. doi: 10.11648/j.ajset.20230801.14

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@article{10.11648/j.ajset.20230801.14,
  author = {Ben Yao and Zhining Xu and Jianan Liu and Liang Yang and Jianping Shang and Jingyuan Fan and Lizhi Ouyang and Hua-Jun Shawn Fan},
  title = {Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide},
  journal = {American Journal of Science, Engineering and Technology},
  volume = {8},
  number = {1},
  pages = {33-41},
  doi = {10.11648/j.ajset.20230801.14},
  url = {https://doi.org/10.11648/j.ajset.20230801.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajset.20230801.14},
  abstract = {Various factors such as solubility, volatility, spray drift, runoff, and photolysis prevent the pesticides to reach their desired location and realize their full potential. In this study, additive manufacturing is used to create a drug-loaded filament that can be used in Fused deposition modeling printing. The optimal printing parameters are printing temperature (170°C), hotbed temperature (25°C), printing speed 15 mm/s, filament diameter 1.55 mm, layer height 0.3 mm, nozzle diameter 0.4 mm and zero retraction speed and retraction distance. The PCL-based framework provides a scaffold for drug encapsulation and low melting temperature. The latter is the key to maintaining the integrity and chemical properties of the loaded drug. FTIR confirms the physical-mix nature of composite. XRD suggests that PCL and model drug became amorphous after printing. The PCL controlled-release can be realized through in vitro dissolution tests. Among the four kinetic models: the zero-order, first-order, Higuchi model, and Korsmeyer–Peppas model, the kinetic model for dissolution and drug release conforms to the Korsmeyer–Peppas model. This study provides a viable design of controlled-release pesticides by adjusting the release regulator content and type to meet the precision pest-control needs. This 3DP tablet has higher drug loading, controllable drug loading, stable drug release ability, UV shielding performance, and an easy manufacturing process. There is no need for expensive and special equipment to produce the desired functionality, which greatly reduces production costs and simplifies the production process.},
 year = {2023}
}

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TY - JOUR
T1 - Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide
AU - Ben Yao
AU - Zhining Xu
AU - Jianan Liu
AU - Liang Yang
AU - Jianping Shang
AU - Jingyuan Fan
AU - Lizhi Ouyang
AU - Hua-Jun Shawn Fan
Y1 - 2023/02/16
PY - 2023
N1 - https://doi.org/10.11648/j.ajset.20230801.14
DO - 10.11648/j.ajset.20230801.14
T2 - American Journal of Science, Engineering and Technology
JF - American Journal of Science, Engineering and Technology
JO - American Journal of Science, Engineering and Technology
SP - 33
EP - 41
PB - Science Publishing Group
SN - 2578-8353
UR - https://doi.org/10.11648/j.ajset.20230801.14
AB - Various factors such as solubility, volatility, spray drift, runoff, and photolysis prevent the pesticides to reach their desired location and realize their full potential. In this study, additive manufacturing is used to create a drug-loaded filament that can be used in Fused deposition modeling printing. The optimal printing parameters are printing temperature (170°C), hotbed temperature (25°C), printing speed 15 mm/s, filament diameter 1.55 mm, layer height 0.3 mm, nozzle diameter 0.4 mm and zero retraction speed and retraction distance. The PCL-based framework provides a scaffold for drug encapsulation and low melting temperature. The latter is the key to maintaining the integrity and chemical properties of the loaded drug. FTIR confirms the physical-mix nature of composite. XRD suggests that PCL and model drug became amorphous after printing. The PCL controlled-release can be realized through in vitro dissolution tests. Among the four kinetic models: the zero-order, first-order, Higuchi model, and Korsmeyer–Peppas model, the kinetic model for dissolution and drug release conforms to the Korsmeyer–Peppas model. This study provides a viable design of controlled-release pesticides by adjusting the release regulator content and type to meet the precision pest-control needs. This 3DP tablet has higher drug loading, controllable drug loading, stable drug release ability, UV shielding performance, and an easy manufacturing process. There is no need for expensive and special equipment to produce the desired functionality, which greatly reduces production costs and simplifies the production process.
VL - 8
IS - 1
ER -

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Author Information

Ben Yao

College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong, China
Zhining Xu

College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong, China
Jianan Liu

College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong, China
Liang Yang

College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong, China
Jianping Shang

College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong, China
Jingyuan Fan

Carnegie Vanguard High School, Houston, USA
Lizhi Ouyang

Department of Physics and Mathematics, Tennessee State University, Nashville, USA
Hua-Jun Shawn Fan

College of Chemical Engineering, Sichuan University of Science and Engineering, Zigong, China

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Plain Text BibTeX RIS

APA Style

Ben Yao, Zhining Xu, Jianan Liu, Liang Yang, Jianping Shang, et al. (2023). Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide. American Journal of Science, Engineering and Technology, 8(1), 33-41. https://doi.org/10.11648/j.ajset.20230801.14

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ACS Style

Ben Yao; Zhining Xu; Jianan Liu; Liang Yang; Jianping Shang, et al. Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide. Am. J. Sci. Eng. Technol. 2023, 8(1), 33-41. doi: 10.11648/j.ajset.20230801.14

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AMA Style

Ben Yao, Zhining Xu, Jianan Liu, Liang Yang, Jianping Shang, et al. Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide. Am J Sci Eng Technol. 2023;8(1):33-41. doi: 10.11648/j.ajset.20230801.14

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@article{10.11648/j.ajset.20230801.14,
  author = {Ben Yao and Zhining Xu and Jianan Liu and Liang Yang and Jianping Shang and Jingyuan Fan and Lizhi Ouyang and Hua-Jun Shawn Fan},
  title = {Design a Viable 3DP Processing for Producing Effective Controlled-Release Pesticide},
  journal = {American Journal of Science, Engineering and Technology},
  volume = {8},
  number = {1},
  pages = {33-41},
  doi = {10.11648/j.ajset.20230801.14},
  url = {https://doi.org/10.11648/j.ajset.20230801.14},
  eprint = {https://article.sciencepublishinggroup.com/pdf/10.11648.j.ajset.20230801.14},
  abstract = {Various factors such as solubility, volatility, spray drift, runoff, and photolysis prevent the pesticides to reach their desired location and realize their full potential. In this study, additive manufacturing is used to create a drug-loaded filament that can be used in Fused deposition modeling printing. The optimal printing parameters are printing temperature (170°C), hotbed temperature (25°C), printing speed 15 mm/s, filament diameter 1.55 mm, layer height 0.3 mm, nozzle diameter 0.4 mm and zero retraction speed and retraction distance. The PCL-based framework provides a scaffold for drug encapsulation and low melting temperature. The latter is the key to maintaining the integrity and chemical properties of the loaded drug. FTIR confirms the physical-mix nature of composite. XRD suggests that PCL and model drug became amorphous after printing. The PCL controlled-release can be realized through in vitro dissolution tests. Among the four kinetic models: the zero-order, first-order, Higuchi model, and Korsmeyer–Peppas model, the kinetic model for dissolution and drug release conforms to the Korsmeyer–Peppas model. This study provides a viable design of controlled-release pesticides by adjusting the release regulator content and type to meet the precision pest-control needs. This 3DP tablet has higher drug loading, controllable drug loading, stable drug release ability, UV shielding performance, and an easy manufacturing process. There is no need for expensive and special equipment to produce the desired functionality, which greatly reduces production costs and simplifies the production process.},
 year = {2023}
}

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